Which conditions are included in the differential diagnoses of complex regional pain syndrome type 1 (CRPS 1) (RSD)?

Updated: Mar 09, 2021
  • Author: T P Sudha Rao, MD; Chief Editor: Herbert S Diamond, MD  more...
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Differential diagnostic considerations include the following [12] :

  • Infection (of bone, soft tissue, joint, or skin)
  • Orthopedic malfixation
  • Joint instability
  • Arthritis or arthrosis
  • Bone or soft tissue injury (eg, stress fracture, instability, ligament damage)
  • Compartment syndrome
  • Neural injury (peripheral nerve damage, including compression or entrapment, or central nervous system or spinal lesions), or neuropathy (such as from diabetes mellitus or alcohol misuse)
  • Thoracic outlet syndrome (due to nerve or vascular compression)
  • Arterial insufficiency (usually after preceding trauma, atherosclerosis in older people, or thrombangiitis obliterans [Burger disease])
  • Raynaud syndrome
  • Lymphatic or venous obstruction
  • Gardner–Diamond syndrome
  • Brachial neuritis or plexitis (Parsonage-Turner syndrome or neuralgic amyotrophy)
  • Erythromelalgia (may include all limbs)
  • Self-harm

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