Which medications in the drug class Sympatholytics are used in the treatment of Complex Regional Pain Syndrome Type 1 (Reflex Sympathetic Dystrophy)?

Updated: Mar 09, 2021
  • Author: T P Sudha Rao, MD; Chief Editor: Herbert S Diamond, MD  more...
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These medications reduce the activity of the sympathetic nervous system.

Clonidine (Catapres)

Stimulates alpha2-adrenoreceptors in brain stem, activating an inhibitory neuron, which in turn results in reduced sympathetic outflow. These effects result in a decrease in vasomotor tone and heart rate.

Phenoxybenzamine (Dibenzyline)

Produces a long-lasting blockade of alpha-adrenergic receptors in smooth muscle and exocrine glands. Blocks epinephrine-induced and norepinephrine-induced vasoconstriction.

Prazosin (Minipress)

Dilates both arteries and veins by blocking postsynaptic alpha1-adrenergic receptors.

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