How is complex regional pain syndrome type 1 (CRPS 1) (RSD) prevented?

Updated: Mar 09, 2021
  • Author: T P Sudha Rao, MD; Chief Editor: Herbert S Diamond, MD  more...
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Knowing the triggers for complex regional pain syndrome (CRPS), especially extremity immobilization for any cause, and recognizing the disease process early and instituting prompt therapy are the most important aspects of prevention.

A retrospective cohort study in 542 patients who underwent subacromial shoulder surgery found that prophylactic use of vitamin C, 500 mg/day orally for 50 days postoperatively, reduced the risk of developing CRPS 1 by more than 50%. The incidence of CRPS 1 in patients who received vitamin C, versus those who did not, was 7% versus 13% (P = 0.009). [35]

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