Which medications in the drug class Antidepressants are used in the treatment of Nonarticular Rheumatism/Regional Pain Syndrome?

Updated: Apr 04, 2018
  • Author: T P Sudha Rao, MD; Chief Editor: Herbert S Diamond, MD  more...
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Some antidepressants provide sedation and relieve chronic pain. They may have a moderate-to-marked sedative effect.

Milnacipran (Savella)

Selective serotonin and norepinephrine reuptake inhibitor (SSNRI). Exact mechanism of central pain inhibitory action and ability to improve symptoms of fibromyalgia unknown. Indicated for fibromyalgia.

Amitriptyline (Elavil)

Analgesic for certain chronic and neuropathic pain.

Sertraline (Zoloft)

SSRI, less sedating than TCAs but appears to improve pain symptoms.

Doxepin (Sinequan)

Inhibits histamine and acetylcholine activity and has proven useful in treatment of various forms of depression associated with chronic and neuropathic pain. Prominent sedative effect. Useful in oral concentrate, 10 mg/mL, to titrate small doses.

Trazodone (Desyrel)

5-HT2–receptor antagonist that inhibits reuptake of 5-HT. Negligible affinity for cholinergic, adrenergic, dopaminergic, or histaminic receptors. Intermediate sedation activity.

Fluoxetine (Prozac)

SSRI, less sedating than TCAs but appears to improve symptoms of pain.

Duloxetine (Cymbalta)

Potent neuronal serotonin inhibitor and norepinephrine reuptake inhibitor. Antidepressive action is theorized to be due to serotonergic and noradrenergic potentiation in CNS.

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