What is the purpose of direct immunofluorescence (DIF) microscopy in the diagnosis of leukocytoclastic vasculitis (LCV)?

Updated: Dec 09, 2020
  • Author: A Brooke W Eastham, MD; Chief Editor: Herbert S Diamond, MD  more...
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Answer

If Henoch-Schönlein purpura is suspected, direct immunofluorescence (DIF) microscopy should be performed to assess for perivascular deposition of IgA. In confirming Henoch-Schönlein purpura by cutaneous biopsy, a kidney biopsy may be avoided in some patients. Biopsy for DIF should be performed within 24-48 hours of the appearance of a lesion.


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