What are the signs and symptoms of a malignant etiology for leukocytoclastic vasculitis (LCV)?

Updated: Dec 09, 2020
  • Author: A Brooke W Eastham, MD; Chief Editor: Herbert S Diamond, MD  more...
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Answer

A study analyzing 421 adult cases of LCV found that 16 patients (3.8%) had an underlying malignancy, including nine hematologic malignancies and seven solid-organ malignancies. The most common presenting sign was palpable purpura, which preceded the diagnosis of malignancy by an average of 17 days. Paraneoplastic LCV was found more commonly in older patients with constitutional symptoms and in those with anemia and immature cells on peripheral smears. [7]

Effective treatment of the malignancy has led to an apparent cure of the vasculitis in some patients.


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