According to the Centers for Disease Control and Prevention (CDC), gonorrhea is the second most commonly reported notifiable disease in the United States, with 616,392 cases reported in 2019. 
The rate of reported gonorrhea cases in the US has been increasing since 2010, after declining from their peak of 467.7 cases per 100,000 population in 1975 to an historic low of 98.1 cases per 100,000 population in 2009. In 2018-2019, gonorrhea rates increased by 5.7%. As of 2019, the national rate of gonococcal infection was 188.4 cases per 100,000 population.  Within the United States, however, rates of infection vary by region (highest in the South and lowest in New England) and by demographics (see below).