What are the organism-related risk factors for disseminated gonococcal infection (DGI)?

Updated: Jul 31, 2018
  • Author: Rachel Robbins, MD; Chief Editor: Herbert S Diamond, MD  more...
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Answer

Organism-related risk factors for DGI include the following [1, 2, 3, 4] :

  • Antigenic variation of pili

  • Protein Por B1A on the outer membrane – This inhibits host factor H and C4-binding protein, making host complement cascade less effective

  • Lack of protein Por B1B

  • Strains with nutritional requirements for arginine, hypoxanthine, and uracil (ie, AHU strains) – These are often associated with protein IA

  • Colony opacity (Opa) protein-independent invasion - Opa proteins are adhesins crucial to the process of N gonorrhoeae attachment to host cells, particularly avoidance of carcinoembryonic antigen-related cell adhesion molecule-3 (CEACAM3) [5]


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