Which medications are used in the inpatient treatment of EGPA (Churg-Strauss syndrome)?

Updated: Dec 02, 2020
  • Author: Spencer T Lowe, MD; Chief Editor: Herbert S Diamond, MD  more...
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Inpatient medications include the following:

  • Prednisone: Start at 0.5-1 mg/kg/d PO.

  • Methylprednisolone is administered in intravenous (IV) form at higher doses in patients with major organ involvement, including cardiac, pulmonary (hemorrhage), renal, or neuropathy.

  • Cyclophosphamide is administered in patients with severe or life-threatening complications. [48, 49] The single IV dose is 500 mg/m2 of body-surface area. The dose should be reduced in patients with renal failure.

  • Other medications include azathioprine, mycophenolate mofetil, and intravenous immune globulin administered similarly as in microscopic polyangiitis or granulomatosis with polyangiitis (Wegener granulomatosis). [50]

  • Plasmapheresis is probably not helpful. [45]

  • Interferon alpha might be helpful in treatment. [51, 52]

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