What are the histologic findings in EGPA (Churg-Strauss syndrome)?

Updated: Dec 24, 2018
  • Author: Spencer T Lowe, MD; Chief Editor: Herbert S Diamond, MD  more...
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The characteristic pathologic changes in EGPA, found especially in the lung, [31, 32] include small necrotizing granulomas, as well as necrotizing vasculitis involving small arteries and venules. The granulomas are composed of a central eosinophilic core surrounded radially by macrophages and epithelioid giant cells. EGPA affects medium-sized and small vessels.

Glomerulonephritis is not as common or severe as in granulomatosis with polyangiitis (Wegener granulomatosis), but, when present, it is usually focal and segmental and indistinguishable from other forms of so-called pauci-immune (without significant tissue deposition of immune complexes) glomerulonephritis. [33, 34]

Eosinophilic granuloma in a patient with Churg-Str Eosinophilic granuloma in a patient with Churg-Strauss syndrome (CSS).

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