What is hypereosinophilic asthma with systemic manifestations and what is its relationship to EGPA (Churg-Strauss syndrome)?

Updated: Dec 24, 2018
  • Author: Spencer T Lowe, MD; Chief Editor: Herbert S Diamond, MD  more...
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Answer

A 2017 study by the Groupe d'Etudes et de Recherche sur les Maladies Orphelines Pulmonaires—conducted in 157 patients with asthma, eosinophilia, and at least one systemic organ manifestation attributable to systemic disease—found that 41% of patients had definite vasculitis manifestations (37%) or strong surrogates of vasculitis (4%), of whom only 53% had ANCA. This group proposed a new entity termed hypereosinophilic asthma with systemic (non-vasculitic) manifestations. The image below depicts transient pulmonary infiltrates. [9]

Transient pulmonary infiltrates in a patient with Transient pulmonary infiltrates in a patient with Churg-Strauss syndrome (CSS).

See Vasculitis: Case Presentations, a Critical Images slideshow, for more information on clinical, histologic and radiographic imaging findings in various forms of vasculitis.


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