Which medications in the drug class Immunomodulatory therapy agents are used in the treatment of Antiphospholipid Syndrome?

Updated: Nov 24, 2020
  • Author: Suneel Movva, MD; Chief Editor: Herbert S Diamond, MD  more...
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Immunomodulatory therapy agents

These agents interfere with processes that promote immune reactions resulting from diverse stimuli.

Intravenous immune globulins, 5% (Gammagard, Gamimune)

Following features may be relevant to efficacy: neutralization of circulating myelin antibodies through antiidiotypic antibodies, down-regulation of proinflammatory cytokines (including IFN-gamma), blockade of Fc receptors on macrophages, suppression of helper/inducer T and B cells and augmentation of suppressor T cells, blockade of the complement cascade, promotion of remyelination, and 10% increase in CSF IgG. May be effective in APS.

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