What are the medications used to treat catastrophic antiphospholipid syndrome (APS)?

Updated: Sep 30, 2018
  • Author: Suneel Movva, MD; Chief Editor: Herbert S Diamond, MD  more...
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Answer

In addition to full anticoagulation, plasma exchange and corticosteroids are generally used in the treatment of CAPS. IVIG or cyclophosphamide may be considered in selected patients with CAPS. However, cyclophosphamide increases the risk of first-trimester fetal loss, so its use in pregnant women should be reserved for severe, life-threatening or refractory manifestations during the second or third trimester. [22]


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