Which lab tests may be helpful in the workup of antiphospholipid syndrome (APS)?

Updated: Sep 30, 2018
  • Author: Suneel Movva, MD; Chief Editor: Herbert S Diamond, MD  more...
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Answer

Patients with APS may have one or more abnormal results from these laboratory tests; the following laboratory tests should be considered in a patient suspected of having APS:

  • aCL antibodies (IgG, IgM)
  • Anti–beta-2 glycoprotein I antibodies (IgG, IgM)
  • Activated partial thromboplastin time (aPTT)
  • LA tests such as DRVVT (A threshold of approximately 1.6 for the DRVVT ratio has been recommended for helping discriminate APS from non-APS. [15] )
  • Serologic test for syphilis (false-positive result)
  • CBC count (thrombocytopenia, hemolytic anemia)

A study of 97 pregnancies in women with a past history of APS concluded that aPL antibodiy profiling to determine obstetric risk is best performed during the first trimester of pregnancy. Latino et al reported that risk categorization performed during pregnancy predicted pregnancy outcome more accurately than categorization performed before pregnancy (91.8% vs 82.5%, respectively). [16]


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