What is the "two-hit" theory of the pathogenesis of antiphospholipid syndrome (APS)?

Updated: Sep 30, 2018
  • Author: Suneel Movva, MD; Chief Editor: Herbert S Diamond, MD  more...
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Answer

A “two-hit” theory has been proposed in which a second risk factor (age, hypertension, diabetes, obesity, smoking, pregnancy, surgery, other genetic hypercoagulable state) incites the thrombotic effects of aPL. [5]


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