Which medications in the drug class Immunosuppressants are used in the treatment of Ankylosing Spondylitis and Undifferentiated Spondyloarthropathy?

Updated: Jun 14, 2022
  • Author: Lawrence H Brent, MD; Chief Editor: Herbert S Diamond, MD  more...
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Immunosuppressants inhibit key factors in the immune system that are responsible for inflammatory responses.

Methotrexate (Trexall, Otrexup, Rasuvo)

Methotrexate has an unknown mechanism of action in AS; it may affect immune function by inhibiting dihydrofolate reductase, interfering with purine synthesis. Effects are observed in the 3-6 weeks following administration. Methotrexate ameliorates symptoms (eg, pain, swelling, stiffness) but there is no evidence that it induces remission. Adjust the dose gradually to obtain a satisfactory response.

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