Which patient groups have the highest prevalence of granulomatosis with polyangiitis (GPA)?

Updated: Oct 09, 2019
  • Author: Christopher L Tracy, MD; Chief Editor: Herbert S Diamond, MD  more...
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Answer

GPA is more common in individuals of northern European descent (approximately 90%); it occurs less commonly in blacks.

In European populations, GPA is slightly more common in men, with a male-to-female ratio of 1.5:1. [31] Women are more likely to have limited disease. [9]

The onset of GPA may occur at any age, although patients typically present at age 35-55 years. GPA is rare in childhood. [32] In a systematic review and meta-analysis of childhood-onset GPA, the age range was 4-18 years. The majority of patients were adolescent girls. [33]


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