What are the ENT signs and symptoms of granulomatosis with polyangiitis (GPA)?

Updated: Oct 09, 2019
  • Author: Christopher L Tracy, MD; Chief Editor: Herbert S Diamond, MD  more...
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Answer

Chronic sinusitis is the most common initial complaint in GPA, occurring in 67% of cases; failure to respond to conventional treatment is suggestive. Other ENT manifestations are as follows:

  • Rhinitis (22%) [1]

  • Epistaxis (11%) [1]

  • Collapse of nasal support, resulting in saddle nose deformity (common)

  • Serous otitis media and hearing loss

  • So-called strawberry gingival hyperplasia

  • Stridor, possibly leading to respiratory compromise, from tracheal or subglottic granulomatous masses


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