Which medications in the drug class Interleukin Inhibitors are used in the treatment of Giant Cell Arteritis (Temporal Arteritis)?

Updated: Sep 03, 2020
  • Author: Mythili Seetharaman, MD; Chief Editor: Herbert S Diamond, MD  more...
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Answer

Interleukin Inhibitors

Adventitial macrophages produce interleukin-6 (IL-6), augmenting the inflammatory response. This results in inflammation with local vascular damage and intimal hyperplasia, leading to stenosis and occlusion. IL-6 antagonists may decrease inflammation from this pathway.

Tocilizumab (Actemra)

Interleukin-6 receptor antagonist. Inhibits IL-6-mediated signaling that results in proinflammatory cytokines. It is indicated for treatment of GCA in adults.


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