Which diagnoses should be included in the differential diagnoses of giant cell arteritis (GCA) (temporal arteritis)?

Updated: Sep 03, 2020
  • Author: Mythili Seetharaman, MD; Chief Editor: Herbert S Diamond, MD  more...
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Answer

Granulomatosis with polyangiitis (formerly known as Wegener granulomatosis) and polyarteritis nodosa may occasionally affect the temporal artery and cause clinical findings similar to GCA. Other vasculitides, such as systemic lupus erythematosus (SLE), rheumatoid arthritis, and Takayasu arteritis, may have similar signs and symptoms.

GCA and Takayasu arteritis have overlapping symptoms in varying frequencies, and when GCA involves larger vessels, the lesions are indistinguishable from those observed in Takayasu arteritis. Thus, these two disorders may represent a spectrum of presentation rather than distinct disease entities. [78]


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