Which medications in the drug class Anticoagulants, Hematologic are used in the treatment of Takayasu Arteritis?

Updated: Nov 14, 2018
  • Author: Jefferson R Roberts, MD; Chief Editor: Herbert S Diamond, MD  more...
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Answer

Anticoagulants, Hematologic

In patients with renal failure due to crescentic glomerulonephritis and nephrotic syndrome, low-dose heparin followed by oral anticoagulation leads to improved renal and systemic function. It probably reduces the destructive effects of fibrin thrombi in the small vessels of the kidney.

Warfarin (Coumadin, Jantoven)

Warfarin interferes with hepatic synthesis of vitamin K ̶ dependent coagulation factors. It is used for the prophylaxis and treatment of venous thrombosis, pulmonary embolism, and thromboembolic disorders.

Tailor the dose to maintain an international normalized ratio (INR) in the range of 2-3.

Heparin

Heparin augments the activity of antithrombin III. It does not actively lyse, but it is able to block further thrombogenesis. Heparin prevents reaccumulation of a clot after a spontaneous fibrinolysis.


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