What is the role of cytotoxic agents in the treatment of Takayasu arteritis?

Updated: Nov 14, 2018
  • Author: Jefferson R Roberts, MD; Chief Editor: Herbert S Diamond, MD  more...
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Cytotoxic agents are used for patients whose disease is steroid resistant or relapsing. These agents are usually continued for at least 1 year after remission and are then tapered to discontinuation. Methotrexate, azathioprine, and cyclophosphamide are among the drugs used in Takayasu arteritis, although success has also been reported with mycophenolate mofetil and tacrolimus. [46] Cyclophosphamide should be reserved for patients with the most severe and refractory disease states.

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