What is a possible biomarker for disease activity in Takayasu arteritis?

Updated: Nov 14, 2018
  • Author: Jefferson R Roberts, MD; Chief Editor: Herbert S Diamond, MD  more...
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Answer

Pentraxin-3 (PTX3), a member of the superfamily of acutephase proteins such as C-reactive protein (CRP) and serum amyloid P, has been suggested as a possible biomarker for identifying disease activity in patients with an established diagnosis of Takayasu arteritis. In a cross-sectional, noninterventional study, PTX3 plasma levels were shown to be more accurate than the erythrocyte sedimentation rate (ESR) and CRP level for differentiating active from inactive disease in 57 patients with previously diagnosed Takayasu arteritis. PTX3 levels greater than 1 ng/mL were more accurate than normal thresholds of CRP and ESR for defining disease activity. Patients with unknown or equivocal disease status were excluded from the study. [36]

Certainly, PTX3 plasma levels may play a future role as a possible disease marker. However as pointed out by the authors of the study, PTX3 needs to be assessed in a broader spectrum of patients whose disease activity is unknown or equivocal before recommending using it clinically. [36]


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