What are the ACR guidelines for the treatment of systemic lupus erythematosus (SLE) nephritis?

Updated: Aug 04, 2021
  • Author: Christie M Bartels, MD, MS; Chief Editor: Herbert S Diamond, MD  more...
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Answer

The 2012 American College of Rheumatology (ACR) guidelines for lupus nephritis recommend that treatment of this condition be largely based on classification by the International Society of Nephrology/Renal Pathology Society (ISN/RPS) histologic criteria (see Biopsies and Histologic Features). [102]

Lupus nephritis is managed with a combination of glucocorticoids [142] and immunosuppressive agents to slow the progression to end-stage renal disease (ESRD), along with maintaining normal blood pressure levels (ie, target of ≤130/80 mm Hg). [64, 102] In general, individuals with class I or II lupus nephritis do not need management with immunosuppression. [102]


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