What is the systemic lupus erythematosus (SLE) Responder Index (SRI)?

Updated: Aug 04, 2021
  • Author: Christie M Bartels, MD, MS; Chief Editor: Herbert S Diamond, MD  more...
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Answer

The SLE Responder Index (SRI) is a tool that was developed following phase II trials and is composed of the following scores [124] :

  • SELENA-SLEDAI (Safety of Estrogens in Lupus Erythematosus: National Assessment– Systemic Lupus Erythematosus Disease Activity Index)

  • BILAG (British Isles Lupus Assessment Group)

  • PGA (physician global assessment)

SRI response is defined by the following [124] :

  • A 4-point or greater reduction in the SELENA-SLEDAI score

  • No new BILAG A or no more than 1 new BILAG B domain score

  • No deterioration from baseline in the PGA by 0.3 or more points.


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