What are the signs and symptoms of systemic lupus erythematosus (SLE)?

Updated: Aug 04, 2021
  • Author: Christie M Bartels, MD, MS; Chief Editor: Herbert S Diamond, MD  more...
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The classic presentation of a triad of fever, joint pain, and rash in a woman of childbearing age should prompt investigation into the diagnosis of SLE. [2, 3] However, patients may present with any of the following types of manifestations [4] :

  • Constitutional

  • Musculoskeletal

  • Dermatologic

  • Renal

  • Neuropsychiatric

  • Pulmonary

  • Gastrointestinal

  • Cardiac

  • Hematologic

In patients with suggestive clinical findings, a family history of autoimmune disease should raise further suspicion of SLE.

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