Which clinical history findings are characteristic of childhood-onset systemic lupus erythematosus (SLE)?

Updated: Aug 04, 2021
  • Author: Christie M Bartels, MD, MS; Chief Editor: Herbert S Diamond, MD  more...
  • Print
Answer

A meta-analysis that reviewed the clinical manifestations of childhood-onset and adult-onset SLE found that Raynaud pleuritis and sicca were twice as common in adults as in children and adolescents. [1]  In contrast, the following manifestations were statistically significantly more common in childhood-onset SLE:

  • Malar rash
  • Ulcers/mucocutaneous involvement
  • Renal involvement, proteinuria, urinary cellular casts
  • Seizures
  • Thrombocytopenia
  • Hemolytic anemia
  • Fever
  • Lymphadenopathy

Did this answer your question?
Additional feedback? (Optional)
Thank you for your feedback!