What is the incidence and prevalence of systemic lupus erythematosus (SLE) in the US?

Updated: Aug 04, 2021
  • Author: Christie M Bartels, MD, MS; Chief Editor: Herbert S Diamond, MD  more...
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Estimates of the annual incidence of SLE from the 1970s to 2000s have ranged from approximately 1 to 10 per 100,000 population, while the prevalence of SLE has been estimated to range from approximately 5.8 to 130 per 100,000 population. [45]

The Lupus Foundation of America estimates prevalence to be at least 1.5 million cases, [46] which likely reflects inclusion of milder forms of the disease. A 2008 report from the National Arthritis Data Working Group estimated a prevalence of 161,000 cases of definite SLE and 322,000 cases of definite or probable SLE. [49]

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