What is the recurrence rate of systemic lupus erythematosus (SLE) in families?

Updated: Aug 04, 2021
  • Author: Christie M Bartels, MD, MS; Chief Editor: Herbert S Diamond, MD  more...
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SLE has a modest recurrence rate in families: 8% of affected patients have at least one first-degree family member (parents, siblings, and children) with SLE; this is in contrast to 0.08% of the general population. [32] In addition, SLE occurs in both twins in 24% of identical twins and 2% of nonidentical twins, which may be due to a combination of genetic and environmental factors. [32]

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