How are digital ulcers treated in scleroderma?

Updated: Sep 09, 2019
  • Author: Sergio A Jimenez, MD, MACR, FACP, FRCP(UK Hon); Chief Editor: Herbert S Diamond, MD  more...
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Answer

Repeated episodes of Raynaud phenomenon in individuals with systemic sclerosis may result in digital ulcers. Bosentan, a dual endothelin receptor antagonist approved for treatment of systemic sclerosis–associated pulmonary hypertension, may curtail the formation of new digital ulcers. [173, 174] Combination therapy with iloprost and bosentan has also shown benefit in reducing new digital ulcers. [175] Ambrisentan and other endothelin receptor antagonists have also shown beneficial effects in preliminary or open label studies. [176, 177]


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