How is skin fibrosis in scleroderma treated?

Updated: Sep 09, 2019
  • Author: Sergio A Jimenez, MD, MACR, FACP, FRCP(UK Hon); Chief Editor: Herbert S Diamond, MD  more...
  • Print
Answer

Numerous experimental drugs or interventions have been investigated for treatment of skin induration and fibrosis in systemic sclerosis. Interventions that have demonstrated benefit include the following:

  • D-penicillamine [146, 147]

  • Bovine collagen [160] - Possible benefit in late-phase disease

  • Methotrexate [141, 142]

  • Mycophenolate mofetil [143, 144, 145]

  • Allogeneic bone marrow transplantation [148, 149, 150, 151, 153, 154, 155]

Interventions that have failed to demonstrate significant benefit for treatment of skin induration and fibrosis in systemic sclerosis include the following:

  • Human relaxin [161]

  • Interferon-alpha [162]

  • Anti–transforming growth factor beta antibodies [163]


Did this answer your question?
Additional feedback? (Optional)
Thank you for your feedback!