When is HSCT indicated for the treatment of scleroderma with pulmonary involvement?

Updated: Sep 09, 2019
  • Author: Sergio A Jimenez, MD, MACR, FACP, FRCP(UK Hon); Chief Editor: Herbert S Diamond, MD  more...
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A review by Sullivan et al of HSCT for patients with scleroderma and pulmonary involvement suggested that indications for referral for HSCT in this population may include the following [159] :

  • Diffuse cutaneous systemic sclerosis with internal organ involvement
  • Age < 65 years
  • Disease duration < 5 years
  • Modified Rodnan skin thickness score (MRSS) >15
  • Early pulmonary involvementj, documented on High-resolution computed tomography (HRCT) and pulmonary function tests (PFTs)

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