What is the prognosis of scleroderma?

Updated: Sep 09, 2019
  • Author: Sergio A Jimenez, MD, MACR, FACP, FRCP(UK Hon); Chief Editor: Herbert S Diamond, MD  more...
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Answer

Survival in patients with diffuse cutaneous disease has improved significantly; currently, the 5-year survival is estimated to be about 80%. Five-year survival in patients with limited cutaneous disease is approximately 90%.

Factors associated with a more severe prognosis are as follows:

  • Younger age

  • African descent

  • Rapid progression of skin symptoms

  • Greater extent of skin involvement

  • Anemia

  • Elevated erythrocyte sedimentation rate (ESR)

  • Pulmonary, renal, and cardiac involvement


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