Which medications in the drug class Chelators are used in the treatment of Rheumatoid Arthritis (RA)?

Updated: Feb 07, 2020
  • Author: Howard R Smith, MD; Chief Editor: Herbert S Diamond, MD  more...
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Chelation therapy in RA may suppress inflammation and arthritis by depressing T-cell activity.

Penicillamine (Cuprimine, Depen)

Penicillamine depresses circulating IgM rheumatoid factor and T-cell activity (but not B-cell activity). It is indicated in patients with severe, active RA who have failed to respond to an adequate trial of conventional therapy.

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