Which medications in the drug class Opioid Analgesics are used in the treatment of Rheumatoid Arthritis (RA)?

Updated: Feb 07, 2020
  • Author: Howard R Smith, MD; Chief Editor: Herbert S Diamond, MD  more...
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Opioid Analgesics

Tramadol has been used to reduce pain in patients with RA. However, this agent only provides analgesic effects and does not have anti-inflammatory properties.

Tramadol (Ultram)

The immediate-release formulation of tramadol is approved for the management of moderate to moderately severe pain in adults. The extended-release formulation is used for the management of moderate to moderately severe chronic pain in adults who require around-the-clock treatment of pain for an extended period of time. Tramadol and its active metabolite (M1) binds to mu-opiate receptors in the central nervous system causing inhibition of ascending pain pathways, altering perception of and response to pain.

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