What are the most common adverse effects of combination therapy for rheumatoid arthritis (RA)?

Updated: Feb 07, 2020
  • Author: Howard R Smith, MD; Chief Editor: Herbert S Diamond, MD  more...
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Answer

The most important and most common adverse events relate to liver and bone marrow toxicity (MTX, SSZ, leflunomide, azathioprine, gold compounds, and D-penicillamine), renal toxicity (cyclosporine, parenteral gold salts, and D-penicillamine), pneumonitis (MTX), allergic skin reactions (gold compounds and SSZ), autoimmunity (D-penicillamine, SSZ, and minocycline), and infections (azathioprine and cyclosporine).


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