Which lab studies are useful in the diagnosis of rheumatoid arthritis (RA)?

Updated: Mar 05, 2021
  • Author: Howard R Smith, MD; Chief Editor: Herbert S Diamond, MD  more...
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Routine viral screening by serologic testing does not significantly facilitate the diagnosis of RA in patients with early RA, nor is it helpful as a potential identifier of disease progression. [42] Potentially useful laboratory studies in suspected RA fall into 3 categories—markers of inflammation, hematologic parameters, and immunologic parameters—and include the following:

  • Erythrocyte sedimentation rate (ESR)

  • C-reactive protein (CRP) level

  • Complete blood count (CBC)

  • Rheumatoid factor (RF) assay

  • Antinuclear antibody (ANA) assay

  • Anti−cyclic citrullinated peptide (anti-CCP) and anti−mutated citrullinated vimentin (anti-MCV) assays (currently used in the 2010 American College of Rheumatology [ACR]/European League Against Rheumatism [EULAR] classification criteria)

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