How are carcinomas differentiated from rheumatoid arthritis (RA)?

Updated: Feb 07, 2020
  • Author: Howard R Smith, MD; Chief Editor: Herbert S Diamond, MD  more...
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A variety of cancers produce paraneoplastic syndromes, including polyarthritis. One form is hypertrophic pulmonary osteoarthropathy, which is most often produced by lung and gastrointestinal carcinomas. Hypertrophic pulmonary osteoarthropathy is characterized by a rheumatoidlike arthritis associated with clubbing, periosteal new bone formation, and a negative RF test. Diffuse swelling of the hands with palmar fasciitis has also been reported with a variety of cancers, especially ovarian carcinoma.

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