What are the ACR–recommended rheumatoid arthritis (RA) disease activity cutoffs?

Updated: Feb 07, 2020
  • Author: Howard R Smith, MD; Chief Editor: Herbert S Diamond, MD  more...
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Answer

In the 2012 ACR-recommended RA disease activity measures, the following indicate disease activity cutoffs for patient-driven composite tools (all 3 scales, 0-10) [2] :

  • PAS and PAS-II – Low/minimal disease, 0.26-3.70; moderate disease, 3.71 to less than 8.0; high/severe disease, 8.00-10.00

  • RAPID-3 – Low/minimal disease, greater than 1.0 to 2.0; moderate disease, greater than 2.0 to 4.0; high/severe disease, greater than 4.0 to 10

For the CDAI patient and provider composite tool (scale, 0-76), low/minimal disease is in the range of greater than 2.8 to 10.00; moderate disease, greater than 10.0 to 22.0; and high/severe disease, greater than 22.0. [2]

The following disease activity cutoffs are for the ACR-recommended RA patient, provider, and laboratory composite tools [2] :

  • DAS28 (ESR or CRP) (scale, 0-9.4) – Low/minimal disease, 2.6 or more to less than 3.2; moderate disease, 3.2 or more to 5.1 or less; high/severe disease greater than 5.1

  • SDAI (scale, 0-86) – Low/minimal disease, greater than 3.3 to 11.0 or less; moderate disease, greater than 11.0 to 26 or less; high/severe disease, greater than 26


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