What are the common extra-articular manifestations of rheumatoid arthritis (RA)?

Updated: Feb 07, 2020
  • Author: Howard R Smith, MD; Chief Editor: Herbert S Diamond, MD  more...
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Answer

RA is a systemic disease, and most individuals with this condition experience extra-articular manifestations such as generalized malaise and fatigue. Rarely, a patient presents with extra-articular manifestations before the onset of arthritis. Some of these manifestations are more common in men (eg, pleural involvement, vasculitis, and pericarditis), but overall, the sex distribution of extra-articular manifestations of the disease is similar to that of RA.


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