What factors correlate with an unfavorable prognosis in rheumatoid arthritis (RA)?

Updated: Feb 07, 2020
  • Author: Howard R Smith, MD; Chief Editor: Herbert S Diamond, MD  more...
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Answer

Nonetheless, predicting the long-term course of an individual case of RA at the outset remains difficult, though the following all correlate with an unfavorable prognosis in terms of joint damage and disability:

  • HLA-DRB1*04/04 genotype

  • High serum titer of autoantibodies (eg, RF and ACPA)

  • Extra-articular manifestations

  • Large number of involved joints

  • Age younger than 30 years

  • Female sex

  • Systemic symptoms

  • Insidious onset


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