Which conditions should be included in the differential diagnoses of reactive arthritis (ReA)?

Updated: Dec 24, 2020
  • Author: Carlos J Lozada, MD; Chief Editor: Herbert S Diamond, MD  more...
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Cutaneous lesions of ReA can mimic the following, but the characteristic clinical picture must raise a suspicion of ReA: Norwegian scabies, mycosis fungoides, subcorneal pustulosis of Sneddon-Wilkinson, atopic dermatitis, acute exanthematic pustulosis, and other causes of erythroderma.

Syphilis may mimic ReA, especially secondary syphilis in its so-called malignant form with polymorphic vesicular pustules covered with thick crusts. [82]

Other conditions to be considered include the following:

  • Immunotherapy/immunization–related arthropathy

  • Synovitis, acne, pustulosis, hyperostosis, and osteomyelitis (SAPHO) syndrome

  • Pyogenic arthritis, pyoderma gangrenosum, and acne (PAPA) syndrome

  • Systemic autoinflammatory disorders

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