Which lab tests are performed in the workup of reactive arthritis (ReA)?

Updated: Dec 24, 2020
  • Author: Carlos J Lozada, MD; Chief Editor: Herbert S Diamond, MD  more...
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Answer

The diagnosis of ReA is clinical, based on the history and physical examination. No laboratory study or imaging finding is diagnostic.

The following laboratory studies may be helpful:

  • White blood cell (WBC) and red blood cell (RBC) counts
  • Erythrocyte sedimentation rate (ESR)
  • C-reactive protein (CRP) and other acute-phase reactants
  • IgA antibodies to specific bacterial antigens
  • Serology and cultures (blood, urine, stool, cervix, urethra), particularly for  Chlamydia
  • Human leukocyte antigen (HLA)–B27
  • Tuberculin skin test
  • HIV
  • Urinalysis

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