Which medications in the drug class Corticosteroids are used in the treatment of Polymyalgia Rheumatica?

Updated: Dec 12, 2018
  • Author: Ehab R Saad, MD, MA, FACP, FASN; Chief Editor: Herbert S Diamond, MD  more...
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Answer

Corticosteroids

These agents cause profound and varied metabolic effects. Their exact mechanism of action in PMR is not well known, but their efficacy may stem from their general anti-inflammatory and immunomodulatory effects. In addition, corticosteroids down-regulate cytokine production.

Prednisone (Deltasone, Rayos)

Prednisone has the capacity to dramatically reduce inflammatory manifestations. Polymyalgia rheumatica is rapidly responsive to low doses of prednisone. However, patients may require treatment for several months to several years.

Prednisolone (Orapred ODT, Veripred 20, Millipred, Millipred DP)

Corticosteroids act as potent inhibitors of inflammation. They may cause profound and varied metabolic effects, particularly in relation to salt, water, and glucose tolerance, in addition to their modification of the immune response of the body. Alternative corticosteroids may be used in equivalent dosage.


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