Which medications in the drug class Nonsteroidal Anti-Inflammatory Drugs are used in the treatment of Polymyalgia Rheumatica?

Updated: Dec 12, 2018
  • Author: Ehab R Saad, MD, MA, FACP, FASN; Chief Editor: Herbert S Diamond, MD  more...
  • Print
Answer

Nonsteroidal Anti-Inflammatory Drugs

These agents can be administered to some patients with mild symptoms; however, patients require corticosteroids for total control of symptoms. NSAIDs may be helpful in later stages of corticosteroid dosage tapering, with close monitoring for drug-related morbidity. NSAIDs generally have no effect on the ESR.

Ibuprofen (I-Prin, Motrin, Caldolor, NeoProfen, Advil, Provil)

Ibuprofen is the drug of choice for patients with mild to moderate pain. It inhibits inflammatory reactions and pain by decreasing prostaglandin synthesis.

Naproxen (Anaprox DS, Aleve, Naprosyn, Naprelan)

Naproxen is indicated for relief of mild to moderate pain. It inhibits inflammatory reactions and pain by decreasing activity of cyclooxygenase, which results in a decrease of prostaglandin synthesis.

Ketoprofen

Ketoprofen is used for relief of mild to moderate pain and inflammation. Small dosages are indicated initially in small patients, elderly patients, and patients with renal or liver disease. Doses higher than 75 mg do not increase the therapeutic effects. Administer high doses with caution, and closely observe the patient’s response.

Indomethacin (Indocin, Tivorbex)

Indomethacin is used for relief of mild to moderate pain; it inhibits inflammatory reactions and pain by decreasing the activity of COX, which results in a decrease of prostaglandin synthesis.

Diclofenac (Cambia, Zipsor, Zorvolex, Dyloject)

Diclofenac inhibits prostaglandin synthesis by decreasing COX activity, which, in turn, decreases formation of prostaglandin precursors.


Did this answer your question?
Additional feedback? (Optional)
Thank you for your feedback!