Which medications in the drug class Antineoplastic agents are used in the treatment of Polyarteritis Nodosa?

Updated: Dec 03, 2018
  • Author: Dana Jacobs-Kosmin, MD, FACP; Chief Editor: Herbert S Diamond, MD  more...
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Antineoplastic agents

These agents are chemically related to nitrogen mustards. Because of its immunomodulatory properties, cyclophosphamide is used in conjunction with glucocorticoids, thus reducing the need for higher corticosteroid doses.


As an alkylating agent, the mechanism of action of the active metabolites of cyclophosphamide may involve cross-linking of deoxyribonucleic acid (DNA), which may interfere with the growth of normal and neoplastic cells.

Methotrexate (Rheumatrex, Trexall)

Methotrexate is a potent anti-inflammatory medication with antiproliferative effects used as a steroid-sparing agent.

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