What is the treatment of choice for cutaneous polyarteritis nodosa (PAN)?

Updated: Dec 17, 2020
  • Author: Dana Jacobs-Kosmin, MD, FACP; Chief Editor: Herbert S Diamond, MD  more...
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As with systemic PAN, the optimal management for cutaneous PAN has not been established. Expert recommendations include agents such as NSAIDs, colchicine, and dapsone, if possible. [76] In more severe cases, steroids and stronger immunosuppressive agents such as cyclophosphamide may be used. Success with mycophenolate mofetil in 2 siblings with treatment-refractory, childhood-onset PAN has also been reported. [77] Methotrexate, azathioprine, and mycophenolate mofetil have been reported as effective therapeutic options after remission is achieved. [78]

Reports of success with other agents such as mizoribine, [79] mycophenolate, and pentoxifylline [80] have been published.

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