What is the role of cyclophosphamide in the treatment of polyarteritis nodosa (PAN)?

Updated: Nov 14, 2017
  • Author: Dana Jacobs-Kosmin, MD, FACP; Chief Editor: Herbert S Diamond, MD  more...
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Answer

Cyclophosphamide therapy may be initiated in patients with serious involvement of major organs or steroid-refractory PAN. [6] Cyclophosphamide can be given as a monthly intravenous (IV) pulse or as a daily pill. IV pulse cyclophosphamide has a rapid onset of action, allows a lower cumulative dose to be administered, and exposes the patient to potential toxicity for shorter periods than an oral regimen. In some cases, however, daily oral cyclophosphamide is needed for a satisfactory therapeutic response.

Administration of IV or oral cyclophosphamide requires close monitoring of blood counts and renal function. Dosing should be adjusted accordingly.


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