How is idiopathic polyarteritis nodosa (PAN) treated?

Updated: Nov 14, 2017
  • Author: Dana Jacobs-Kosmin, MD, FACP; Chief Editor: Herbert S Diamond, MD  more...
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Answer

The optimal management for polyarteritis nodosa (PAN) has not been established. Trial results in PAN are difficult to interpret, as many were conducted prior to the creation of the CHCC definition and included patients with MPA and Churg-Strauss syndrome. Corticosteroids have shown a clear benefit in these vasculitides, resulting in improvement of 5-year survival rates to 50%. [61] Cyclophosphamide may improve the survival rate in patients with severe disease. [62]


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