What are the neurologic symptoms of polyarteritis nodosa (PAN)?

Updated: Dec 03, 2018
  • Author: Dana Jacobs-Kosmin, MD, FACP; Chief Editor: Herbert S Diamond, MD  more...
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Neurologic symptoms in PAN include the following:

  • Sensory and/or motor neuropathies - When these occur, they are usually asymmetrical

  • Mononeuritis multiplex (multiple mononeuropathy) - This is the successive ischemia or infarction of "named nerves" (eg, ulnar, radial, peroneal, sural). Although nerve involvement is initially asymmetrical, the development of additional nerve lesions can cause the clinical picture to resemble symmetrical polyneuropathy. (A history of asymmetry at the onset and by electrodiagnostic studies can be helpful in this case.) [45]

  • CNS involvement - Although rare (≤10% of cases), encephalopathy, focal deficits, strokes, seizures, and, sometimes, brain hemorrhages can occur. [45, 46]

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